First human trial looms for Rinri's cell therapy to regenerate inner ear nerve connections to brain

2025 could see major successes in the use of regenerative cell therapy to replace the inner ear’s dead or damaged sensory cells that cause sensorineural hearing loss. One UK-based company claims to be ahead of the pack in these techniques aimed at reversing the condition for which no pharmaceutical therapies are currently available.

Peter WIX, Published on 02 December 2024

First human trial looms for Rinri’s cell therapy to regenerate inner ear nerve connections to brain
The principal cause of hearing conditions such as age-related hearing loss (presbycusis) and auditory neuropathy spectrum disorder (ANSD) is the loss of nerve connections in the ear.  Consider that such conditions affect over 100 million people worldwide, and you get a sense of what it would mean if those nerve connections could be regenerated. [caption id="attachment_139269" align="alignright" width="300"] © Rinri Therapeutics[/caption] In the leading pack of outfits looking for this regenerative route through gene therapy is Rinri Therapeutics, which is backed by leading investors Boehringer Ingelheim Venture Fund, UCB Ventures, Pioneer, and The University of Sheffield, (plus non-dilutive funding). Rinri's scientific team has developed a product, Rincell-1, that uses the pioneering...

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